Reducing the Need for HLA-Matched Platelet Transfusion
نویسندگان
چکیده
Reducing the Need for HLA-Matched Platelet Transfusion Some patients with acute leukemia or myelodysplastic syndromes thrombocytopenia may become resistant to random donor transfusions of plat...
منابع مشابه
HLA-matched platelet transfusion therapy of severe aplastic anemia.
In order to define more clearly the importance of the degree of HLA compatibility in the hematologic support of patients refractory to random-donor platelets, we retrospectively analyzed over 1 000 platelet transfusions given during stable periods of their disease to 1 1 thrombocytopenic, severely alloimmunized patients with aplastic anemia: 28% of the donors fully matched with the recipient fo...
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متن کاملPatients Patient Percent Response to Unmatched Transfusion Response to HLA - Matched Transfusion
The effect of splenectomy on the response to random donor platelet transfusion in 1 5 multitransfused thrombocytopenic patients is presented. Eight patients responded poorly, with low corrected platelet count increments at 1 and 24 hours posttransfusion. These eight patients were clinically alloimmunized and had lymphocytotoxic antibody (ICTAb) in their sera. They responded well to closely HLA-...
متن کاملCorrection of poor platelet transfusion responses with leukocyte-poor HL-A-matched platelet concentrates.
Matching donor-recipient pairs for HL-A antigens provides a logical starting point for selecting donors for recipients with extensive prior transfusion histories. However, during the course of continued exposure to even HL-A-matched platelet concentrates, further sensitization occurs, as indicated by progressively poorer post-transfusion increments and transfusion reactions. There is evidence t...
متن کاملThe influence of a partially HLA-matched blood transfusion on the disease activity of rheumatoid arthritis.
OBJECTIVE Based on the immunosuppressive effects of blood transfusions in organ transplantation, we determined the effect of a blood transfusion on disease activity of rheumatoid arthritis (RA). METHOD In this double-blind pilot study, 40 patients with active RA were randomly assigned to receive a HLA-DRB1-matched blood transfusion (n = 30) or placebo (n = 10). Disease activity was scored acc...
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ژورنال
عنوان ژورنال: The New England Journal of Medicine
سال: 2021
ISSN: ['0028-4793', '1533-4406']
DOI: https://doi.org/10.1056/nejmc2034764